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Related Experiment Videos

Endogenous protein-synthesis efficiency in trauma victims.

M Jeevanandam1, D H Young, W R Schiller

  • 1Trauma Center, St Joseph's Hospital & Medical Center, Phoenix, AZ 85013.

Metabolism: Clinical and Experimental
|October 1, 1989
PubMed
Summary

In major trauma patients, protein synthesis efficiency is significantly reduced, indicating amino acid diversion from protein building. This impacts early nutritional management strategies for trauma survivors.

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Area of Science:

  • Biochemistry
  • Trauma Medicine
  • Metabolic Research

Background:

  • Hyperglycemia and hypoaminoacidemia are common in hypermetabolic, catabolic trauma patients.
  • The reutilization of endogenous amino acids for protein synthesis (protein recycling) in trauma is not well understood.

Purpose of the Study:

  • To measure protein synthesis efficiency in multiple trauma patients during the early "flow" phase.
  • To compare protein synthesis efficiency in trauma patients with normal and depleted states.

Main Methods:

  • Measured protein synthesis efficiency in ten multiple trauma patients.
  • Compared data with normal and depleted patient groups.

Main Results:

  • Protein synthesis efficiency in acute trauma was significantly low (61% +/- 4%).

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  • This is considerably lower than in other pathological states (78% +/- 1%).

    • Conclusions:

    • Acute trauma prioritizes glucose production, diverting amino acids from protein synthesis.
    • This reduced efficiency necessitates consideration in early trauma patient management before exogenous amino acid adaptation.