Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

2.0K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
2.0K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.8K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.8K
Long-Term Memory01:18

Long-Term Memory

937
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
937
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

1.9K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Far transfer of retrieval-practice benefits: rule-based learning as the underlying mechanism.

Cognitive research: principles and implications·2024
Same author

Mind wandering during hypertext reading: The impact of hyperlink structure on reading comprehension and attention.

Acta psychologica·2023
Same author

Concurrent prospective memory task increases mind wandering during online reading for difficult but not easy texts.

Memory & cognition·2022
Same author

In search for the most optimal EEG method: A practical evaluation of a water-based electrode EEG system.

Brain and neuroscience advances·2021
Same author

Error-Related Cognitive Control and Behavioral Adaptation Mechanisms in the Context of Motor Functioning and Anxiety.

Frontiers in human neuroscience·2021
Same author

Motor and non-motor sequence prediction is equally affected in children with developmental coordination disorder.

PloS one·2020
Same journal

Preface.

Frontiers of neurology and neuroscience·2021
Same journal

Hypocretin/Orexin, Sleep and Alzheimer's Disease.

Frontiers of neurology and neuroscience·2021
Same journal

Sleep and Metabolism: Implication of Lateral Hypothalamic Neurons.

Frontiers of neurology and neuroscience·2021
Same journal

The Insomnia-Addiction Positive Feedback Loop: Role of the Orexin System.

Frontiers of neurology and neuroscience·2021
Same journal

Heterogeneity of Hypocretin/Orexin Neurons.

Frontiers of neurology and neuroscience·2021
Same journal

Hypocretin/Orexin Receptor Pharmacology and Sleep Phases.

Frontiers of neurology and neuroscience·2021
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

18.4K

Memory function and the hippocampus.

Bertram Opitz1

  • 1Department of Psychology, University of Surrey, Guildford, UK.

Frontiers of Neurology and Neuroscience
|April 30, 2014
PubMed
Summary
This summary is machine-generated.

The hippocampus binds item and context information for recollection, while surrounding areas signal familiarity. Understanding declarative memory requires considering medial temporal lobe interactions with other brain regions.

More Related Videos

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
07:14

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

3.7K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

7.7K

Related Experiment Videos

Last Updated: Apr 30, 2026

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

18.4K
Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
07:14

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

3.7K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

7.7K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Memory Research

Background:

  • The medial temporal lobe, particularly the hippocampus, is traditionally viewed as crucial for declarative memory.
  • Ongoing debate exists regarding the specific computational roles of hippocampal substructures in memory processing.

Purpose of the Study:

  • To summarize various accounts of hippocampal functions in memory.
  • To explore the cognitive processes, information handled, and neural operations involved.
  • To differentiate the roles of recollection and familiarity in memory.

Main Methods:

  • Review of existing literature and evidence on hippocampal function.
  • Analysis of cognitive processes distinguishing recollection and familiarity.
  • Examination of neural coding mechanisms in the hippocampus and surrounding cortical areas.

Main Results:

  • The hippocampus utilizes sparse conjunctive neural coding to bind item and spatiotemporal context, forming the basis of recollection.
  • Surrounding cortical areas employ broader neural coding, providing similarity signals for familiarity.
  • Interactions between the medial temporal lobe and other brain regions are essential for a comprehensive understanding of declarative memory.

Conclusions:

  • The hippocampus plays a distinct role in memory by binding item and context for recollection.
  • Cortical areas contribute to familiarity through similarity-based coding.
  • A holistic view of declarative memory necessitates integrating medial temporal lobe functions with broader neural network interactions.