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Long-term outcome of parapneumonic effusions in children: Lung function and exercise tolerance

Kalliopi Kontouli1, Elpis Hatziagorou1, Fotis Kyrvasilis1

  • 13rd Paediatric Dept, Paediatric Pulmonology Unit, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.

Pediatric Pulmonology
|April 30, 2014
PubMed

Insights

Long-term outcomes for children with parapneumonic effusions (PPE) show minor lung function changes, with no clinical impact. Pre-existing asthma did not significantly alter these results.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Outcomes Research

Background:

  • Parapneumonic effusions (PPE) are common in children.
  • Long-term sequelae of pediatric PPE require further investigation.
  • The influence of comorbid asthma on PPE outcomes is not fully understood.

Purpose of the Study:

  • To assess the long-term lung function and exercise tolerance in children following PPE.
  • To determine if pre-existing asthma affects the long-term outcomes of pediatric PPE.

Main Methods:

  • A cohort of 51 children with prior PPE was evaluated at least 2 years post-infection.
  • Children were stratified into groups with and without prior asthma.
  • Spirometry and maximal incremental cardiopulmonary exercise testing were performed and compared to healthy controls.

Main Results:

  • Children with a history of PPE exhibited reduced FVC%, FEV1%, and FEV1/FVC compared to controls.
  • Children with PPE and asthma showed lower FEF(25-75%) and FEV1/FVC compared to controls and the PPE-only group, respectively.
  • Maximal exercise capacity (VO2max) was similar across all groups; however, children with PPE had higher VE/VO2 during exercise.

Conclusions:

  • Pediatric PPE results in minor, clinically insignificant long-term effects on lung function and exercise capacity.
  • Pre-existing asthma does not appear to significantly modify the long-term pulmonary outcomes after PPE.
  • Children with a history of PPE may experience subtle changes in respiratory efficiency during exercise.
Abstract

Keywords:
asthmaempyemaexercisepleural disease

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