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Updated: Apr 30, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Genetics of lymphocytes influences the emergence of second cancer in chronic lymphocytic leukemia
Marta Bernués1, Maria Antònia Durán, Guiomar Puget
1Hospital Universitari Son Espases, Genetics Department, Cra. Valldemossa 79, 07120 Palma de Mallorca, Mallorca, Balearic islands, Spain. marta.bernues@ssib.es.
Background:
Patients affected by chronic lymphocytic leukemia (CLL) have an increased risk of developing a second cancer. There is not a definitive explanation for this phenomenon, although some hypotheses have been postulated. The aim of the present work was to assess the presence of second cancer in untreated patients with CLL who were cytogenetically characterized, and secondly to investigate if there is a correlation between the genetics of CLL and the emergence of second cancer.
Patients And Methods:
We performed conventional cytogenetics and Fluorescent in situ hybridization analyses in a series of 106 patients.
Results:
We observed that nearly 8% of cases developed second cancer, mostly epithelial tumors. The majority of them presented two common features, del(13)(q14.3) and the presence of at least two genetic alterations.
Conclusion:
We suggest that the genetic background of CLL, particularly the presence of several genetic alterations, influences the emergence of second cancer in patients affected by CLL.
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