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Updated: Apr 30, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Clinicopathological and prognostic significance of FOXM1 expression in esophageal squamous cell carcinoma
Akihiro Takata1, Shuji Takiguchi, Kaoru Okada
1Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University 2-2, E2, Yamadaoka, Suita, Osaka 565-0871, Japan. stakiguchi@gesurg.med.osaka-u.ac.jp.
Background:
Esophageal squamous cell carcinoma (ESCC) has a poor prognosis because invasion and metastasis are prevalent. To improve diagnosis, it is important to identify and characterize tumor-specific molecular markers in ESCC. FOXM1 is overexpressed and correlates with pathogenesis in a variety of human malignancies. We aimed to investigate the clinical significance of FOXM1 overexpression in ESCC.
Patients And Methods:
FOXM1 expression was assessed in ESCC specimens from 174 curatively-resected cases. The relationships between FOXM1 expression, clinicopathological parameters, and prognoses were examined.
Results:
Immunohistochemical analysis showed that 94 (54.0%) tumors were positive for FOXM1 expression. FOXM1 positivity did not correlate with any clinicopathological parameter. However, FOXM1-positive cases had poorer prognoses than FOXM1-negative ones (p=0.0037, log-rank test). In multivariate analysis, the following were independent prognostic factors: pT, pN, neoadjuvant chemotherapy, and FOXM1 expression (hazard ratio=1.69, 95% confidence interval=1.06-2.75, p=0.027).
Conclusion:
FOXM1 may be a novel prognostic factor in patients with ESCC who undergo curative resection.
