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Related Concept Videos

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The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
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Related Experiment Video

Updated: Apr 30, 2026

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
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C. elegans as a model for membrane traffic.

Ken Sato1, Anne Norris, Miyuki Sato

  • 1Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan. sato-ken@gunma-u.ac.jp; grant@biology.rutgers.edu.

Wormbook : the Online Review of C. Elegans Biology
|April 30, 2014
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Summary
This summary is machine-generated.

Membrane trafficking via endocytosis and secretory pathways is crucial for cell homeostasis. Research in Caenorhabditis elegans provides key insights into these fundamental cellular processes.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Endocytosis and secretory pathways maintain plasma membrane composition and cellular homeostasis.
  • These pathways are integral to intercellular signaling and cellular function.
  • Membrane trafficking is essential for rapid cellular responses to environmental changes.

Purpose of the Study:

  • To review progress in understanding membrane trafficking mechanisms.
  • To highlight insights derived from studies in Caenorhabditis elegans.
  • To focus on non-neuronal cell types.

Main Methods:

  • Review of existing literature on membrane trafficking in C. elegans.
  • Analysis of studies focusing on cargo sorting, vesicle budding, and membrane dynamics.
  • Examination of research in specific non-neuronal cell types.

Main Results:

  • C. elegans research has illuminated diverse roles of membrane trafficking in physiology and development.
  • Molecular mechanisms of cargo sorting, vesicle budding, and membrane fusion/fission have been elucidated.
  • Significant progress has been made in understanding these processes in non-neuronal cells.

Conclusions:

  • Caenorhabditis elegans is a powerful model for dissecting fundamental membrane trafficking mechanisms.
  • Understanding these pathways is critical for cell biology and developmental processes.
  • Further research in C. elegans continues to advance our knowledge of cellular dynamics.