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Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator
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Neutrophil homeostasis and its regulation by danger signaling

Stefan Wirths1, Stefanie Bugl1, Hans-Georg Kopp1

  • 1Department of Medical Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, South West German Comprehensive Cancer Center, University Hospital of Tuebingen, Tuebingen, Germany.

Blood
|April 30, 2014
PubMed

Hematopoiesis in general is demand driven and adaptive, but in contrast to erythropoiesis or thrombocytopoiesis, our knowledge on how neutrophil production is adapted to individual needs remains incomplete. Recently, neutrophil homeostasis has been shown to depend on danger receptors, macrophages, and even circadian rhythms. Puzzle pieces for a broader view of neutrophil homeostasis accumulate, and we will herein try to put seemingly contradictory evidence in a perspective of neutrophil homeostasis and emergency granulopoiesis determined by innate immunologic signaling.

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