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Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates
Andreas Hoeflich1, Elisa Wirthgen2, Robert David3
1Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN) , Dummerstorf , Germany.
Abstract:
IGFBP-2 (1) has been described as a brain tumor oncogene (2) and is widely expressed in cancers from different origins (3-8). IGFBP-2 alone cannot cause malignant transformation, yet progression of brain tumors to higher grade (9) and also has been provided as a protective element in earlier stages of multistage colon carcinogenesis (10). Therefore, it is crucial to understand the factors that determine expression patterns of IGFBP-2 under normal and malignant conditions. The present review provides a comprehensive update of known factors that have an impact on expression of IGFBP-2.
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