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Giant clival chordoma causing pathological laughter.

Daniel Andrade Gripp1, Antonio Aversa do Souto1, Douglas Gonsales1

  • 1Department of Neurosurgery, National Institute of Cancer, INCA, Centro, Rio de Janeiro, Brazil.

Surgical Neurology International
|April 30, 2014
PubMed
Summary
This summary is machine-generated.

Chordomas, rare tumors from notochord remnants, can cause neurological symptoms. This case highlights pathological laughter as an unusual symptom, often improving with brain stem decompression.

Keywords:
Chordomaclivuspathological laughter

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Area of Science:

  • Neuro-oncology
  • Neurosurgery

Background:

  • Chordomas are rare, slow-growing malignant tumors originating from notochordal remnants.
  • They exhibit aggressive local behavior, leading to bone infiltration and neurovascular compression.

Observation:

  • A rare case of a 42-year-old male presenting with pathological laughter associated with a brain tumor is described.
  • This atypical clinical presentation prompted further investigation and literature review.

Findings:

  • Pathological laughter is an exceptionally rare symptom associated with chordomas.
  • The study discusses the limited existing literature on brain tumors and pathological laughter.

Implications:

  • While rare, pathological laughter in chordoma cases may indicate brain stem involvement.
  • Surgical decompression of the brain stem is a potential therapeutic strategy for improving this symptom.