Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

24
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

460
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
460
Inflammation01:38

Inflammation

46.6K
Overview
46.6K
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

21
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
21
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

19
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
19
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

20
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
20

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental growth factor (PLGF)-based testing to help diagnose suspected pre-eclampsia: a systematic review and economic evaluation.

Health technology assessment (Winchester, England)·2026
Same author

Effects of single-injection vs. continuous brachial plexus blocks for shoulder surgeries on patient-reported outcomes: a systematic review and meta-analysis with trial sequential analysis of randomised controlled trials.

Anaesthesia·2026
Same author

Postoperative Delirium and Neurocognitive Disorders Associated With Inflammatory and Neuronal Injury Biomarkers: A Prospective, Longitudinal, Cohort Study.

Anesthesia and analgesia·2026
Same author

Routine pre-operative modified telephone interview for cognitive status screening: a reply.

Anaesthesia·2026
Same author

Intraoperative electroencephalogram-derived measures and their association with postoperative delirium. Response to Br J Anaesth 2026; 136: 1055-56.

British journal of anaesthesia·2026
Same author

LncRNA-HLX-2-7/HLX axis-dependent metabolic reprogramming drives cancer progression in group 3 medulloblastoma.

Acta neuropathologica communications·2026

Related Experiment Video

Updated: Apr 30, 2026

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
07:18

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Published on: April 14, 2023

2.2K

Cardiac surgery, the brain, and inflammation.

David A Scott, Lisbeth A Evered, Brendan S Silbert

    The Journal of Extra-Corporeal Technology
    |May 1, 2014
    PubMed
    Summary

    Postoperative cognitive dysfunction is a concern years after surgery, especially in cardiac patients. Pre-existing cognitive issues and inflammation may accelerate long-term cognitive decline.

    Area of Science:

    • Neuroscience
    • Gerontology
    • Anesthesiology

    Background:

    • Cognitive deterioration is measurable after anesthesia and surgery.
    • Cardiac surgery has high reported incidence of postoperative cognitive dysfunction.
    • Early postoperative cognitive dysfunction differs from long-term effects.

    Purpose of the Study:

    • To investigate long-term cognitive changes after surgery.
    • To understand the role of preoperative cognitive status.
    • To explore the impact of inflammatory responses on cognitive decline.

    Main Methods:

    • Analysis of cognitive status at 3 months, 12 months, and 5 years post-surgery.
    • Assessment of preoperative cognitive impairment, including mild cognitive impairment.
    • Measurement of inflammatory markers and their effect on the blood-brain barrier.

    More Related Videos

    A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
    08:17

    A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

    Published on: February 27, 2018

    19.7K
    A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
    06:50

    A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

    Published on: June 10, 2020

    2.0K

    Related Experiment Videos

    Last Updated: Apr 30, 2026

    Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
    07:18

    Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

    Published on: April 14, 2023

    2.2K
    A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
    08:17

    A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

    Published on: February 27, 2018

    19.7K
    A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
    06:50

    A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

    Published on: June 10, 2020

    2.0K

    Main Results:

    • Up to one-third of elective cardiac surgical patients have pre-existing cognitive impairment.
    • Inflammatory responses and pre-existing conditions can compromise the blood-brain barrier.
    • Inflammation may accelerate neurological decline in susceptible individuals.

    Conclusions:

    • Preoperative cognitive status is a significant factor in perioperative risk.
    • Inflammation during surgery can initiate accelerated long-term cognitive decline.
    • Evidence for effective preventive or therapeutic strategies remains limited.