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Updated: Apr 30, 2026

Murine Fetal Echocardiography
Published on: February 15, 2013
Application of two-dimensional echocardiography combined with enhanced flow in diagnosing fetal heart malformation
Objective:
The current study aims to evaluate the diagnostic accuracy of two-dimensional echocardiography combined with enhanced flow (e-flow) imaging for fetal heart malformation.
Materials And Methods:
A total of 1,639 pregnant women were enrolled. They were examined using fetal echocardiography combined e-flow. The obtained results were compared with those by postnatal examination or post-induction autopsy.
Results:
Complete data were obtained from 1,286 out of the 1,639 fetuses (78.46%). Two-dimensional echocardiography combined with e-flow imaging had sensitivity, specificity, a misdiagnosis rate, and a missed diagnosis rate of 98.0%, 99.3%, 2.0%, and 0.7%, respectively. It has a consistency evaluation Kappa value of 0.970 (p = 0.000).
Conclusion:
Two-dimensional echocardiography combined with e-flow is an accurate and reliable diagnostic method for fetal heart malformation. It has high sensitivity and specificity.
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