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Clear cell ependymoma. A histological variant with diagnostic implications.
N Kawano1, K Yada, S Yagishita
1Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan.
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1989
Summary
This study identifies "clear cell ependymoma," a rare brain tumor. Histological analysis confirmed its ependymal origin, distinguishing it from similar tumors like oligodendroglioma.
Area of Science:
- Neuro-oncology
- Surgical Pathology
- Cell Biology
Background:
- Cystic brain tumors pose diagnostic challenges.
- Accurate classification is crucial for effective treatment and prognosis.
- Tumors within or near the ventricular system require careful histological evaluation.
Observation:
- Four cystic brain tumors (frontal lobe, third ventricle, cerebellum) were analyzed.
- Histology revealed a honeycomb pattern with clear cells.
- Immunostaining showed glial fibrillary acidic protein (GFAP) positivity in some cells.
Findings:
- Electron microscopy confirmed ependymal cell origin, evidenced by microvilli and cilia.
- Tumor cells exhibited clear cytoplasm and well-developed intercellular junctions.
- The distinct features differentiate these tumors from oligodendroglioma and hemangioblastoma.
Implications:
- Proposes the term "clear cell ependymoma" to improve diagnostic accuracy.
- Highlights the importance of detailed histological and ultrastructural analysis.
- Aids in preventing misdiagnosis of common brain tumors.