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Related Concept Videos

Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

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Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
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Lipids as Anchors01:32

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In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
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Factors Affecting Protein-Drug Binding: Protein-Related Factors01:20

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Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
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Fats as Energy Storage Molecules01:06

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Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

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Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
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What are Lipids?01:38

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Overview
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Related Experiment Video

Updated: Apr 30, 2026

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
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Fatty acid-binding proteins at a glance.

Yadong Zheng1

  • 11 Xujiaping, Yanchangbu, Lanzhou 730046, Gansu, China. zhengyadong@caas.cn.

Protein and Peptide Letters
|May 1, 2014
PubMed
Summary

Fatty acid-binding proteins (FABPs) are crucial for fatty acid metabolism and have roles in immune responses and tumor development. Research is expanding the known functions of FABPs beyond their traditional roles.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Fatty acid-binding proteins (FABPs) are a family of intracellular proteins involved in fatty acid metabolism.
  • FABPs exhibit conserved secondary structures despite varying amino acid identities (20%-70%).
  • Beyond lipid transport, FABPs are implicated in immune cell cytokine production, tumor growth, and angiogenesis.

Purpose of the Study:

  • To explore the diverse biological functions of FABPs.
  • To highlight the expanding roles of FABPs beyond lipid metabolism.

Main Methods:

  • Literature review of studies on FABP functions.
  • Analysis of conserved structural features and functional associations.

Main Results:

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  • FABPs play multifaceted roles in cellular processes.
  • Evidence links FABPs to immune regulation and oncogenesis.
  • Structural conservation suggests shared functional mechanisms.

Conclusions:

  • FABP functions extend significantly beyond lipid handling.
  • FABPs are critical regulators in immunity and cancer biology.
  • Further research is warranted to fully elucidate FABP mechanisms.