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Related Experiment Video

Updated: Apr 30, 2026

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Fumaric acid esters in psoriasis and multiple sclerosis.

C Zecca¹, M Caporro, M Adami

¹Department of Neurology, Neurocenter of Southern Switzerland, Ospedale Regionale, Lugano, Switzerland.

Clinical and Experimental Dermatology

|May 1, 2014

Summary

This summary is machine-generated.

Fumaric acid esters (FAEs) effectively treated severe plaque psoriasis in a multiple sclerosis (MS) patient unresponsive to other therapies. This suggests FAEs may benefit MS patients with treatment-induced psoriasis.

Related Experiment Videos

Last Updated: Apr 30, 2026

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Area of Science:

Dermatology and Neurology
Immunomodulatory Therapies

Background:

Psoriasis and multiple sclerosis (MS) are chronic inflammatory conditions.
Fumaric acid esters (FAEs) and dimethylfumarate show efficacy in psoriasis and MS, respectively.
Immune-modulating agents, like interferon-β-1a, can induce or exacerbate psoriasis.

Observation:

A patient with MS developed severe plaque psoriasis during interferon-β-1a therapy.
The patient's psoriasis was refractory to topical treatments and phototherapy.
Dimethylfumarate (a component of FAEs) is used for relapsing MS.

Findings:

The patient received FAEs at 720 mg daily.
Complete remission of psoriatic lesions was observed.
Neurological stabilization was maintained over 24 months of follow-up.

Implications:

FAEs may be a viable treatment option for plaque psoriasis in MS patients.
This approach could be particularly useful for psoriasis induced by immune-modulating agents.
Further research into FAEs for managing comorbidities in MS is warranted.