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Updated: Apr 30, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

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The ins and outs of fibroblast growth factor receptor signalling

Stacey J Coleman1, Charo Bruce1, Athina-Myrto Chioni1

  • 1*Centre for Tumour Biology, Barts Cancer Institute-a CRUK Centre of Excellence, Queen Mary University of London, London EC1M 6BQ, U.K.

Clinical Science (London, England : 1979)
|May 1, 2014
PubMed

Insights

Fibroblast growth factor receptor (FGFR) signaling is crucial in cancer. This review highlights FGFR

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • Fibroblast growth factor receptor (FGFR) signaling is vital in development, physiology, and disease, particularly in various cancers.
  • While canonical downstream pathways in cancer cells are understood, emerging research points to FGFR's roles in stromal interactions and the nucleus.
  • The tumor microenvironment (stroma) is recognized for its influence on cancer progression and treatment response.

Purpose of the Study:

  • To review emerging research on fibroblast growth factor receptor (FGFR) signaling in cancer.
  • To focus on two under-explored areas: FGFR's role in cancer-associated stromal cross-talk and its potential functions within the cell nucleus.
  • To underscore the clinical relevance and interconnectedness of these FGFR signaling aspects, especially in pancreatic cancer.

Main Methods:

  • Literature review of recent studies on fibroblast growth factor receptor (FGFR) signaling in cancer.
  • Synthesis of evidence regarding FGFR's involvement in stromal interactions and nuclear functions.
  • Analysis of clinical implications and potential therapeutic targeting strategies.

Main Results:

  • FGFR signaling significantly influences cancer progression through cross-talk with the tumor stroma.
  • Evidence suggests FGFR signaling pathways operate within the cell nucleus, impacting cancer biology.
  • These stromal and nuclear roles of FGFR are clinically relevant and interconnected, notably in pancreatic cancer.

Conclusions:

  • Emerging evidence highlights the critical, yet underappreciated, roles of fibroblast growth factor receptor (FGFR) signaling in cancer progression via stromal interactions and nuclear functions.
  • Further investigation into these areas offers promising avenues for novel cancer therapies, particularly targeting receptor tyrosine kinases.
  • The study emphasizes the need to consider FGFR's broader biological context beyond cancer cells for effective therapeutic strategies.

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