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Association between TLR1 polymorphisms and alopecia areata.

Hosik Seok1, Dong Woo Suh, Byungchul Jo

  • 1Department of Pharmacology and Kohwang Medical Research Institute, College of Medicine, Kyung Hee University , Seoul , Republic of Korea .

Autoimmunity
|May 1, 2014
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Summary

Genetic variations in the Toll-like receptor 1 (TLR1) gene may influence alopecia areata (AA) development. The study found a significant association between TLR1 SNP rs4833095 and AA susceptibility in the Korean population.

Keywords:
Alopecia areataTLR1single nucleotide polymorphisms

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Area of Science:

  • Immunogenetics
  • Dermatology
  • Human Genetics

Background:

  • Toll-like receptors (TLRs) play a role in autoimmune responses.
  • Autoimmune attacks on hair follicles are implicated in alopecia areata (AA).
  • The genetic contribution of TLR1 polymorphisms to AA is not well understood.

Purpose of the Study:

  • To investigate the association between Toll-like receptor 1 (TLR1) gene single nucleotide polymorphisms (SNPs) and the susceptibility to alopecia areata (AA).
  • To explore the relationship between TLR1 gene polymorphisms and the clinical features of AA.

Main Methods:

  • A case-control study was conducted with 239 AA patients and 248 controls.
  • Two TLR1 SNPs (rs4833095 and rs5743557) were genotyped.
  • Multiple logistic regression was used to analyze associations with AA development and clinical characteristics.

Main Results:

  • The missense SNP rs4833095 in TLR1 showed a significant association with AA development (p < 0.007).
  • The promoter SNP rs5743557 exhibited a weaker association with AA development (p < 0.032).
  • Rs4833095 was also weakly associated with age of onset between 15 and 50 years (p < 0.043).

Conclusions:

  • The TLR1 gene polymorphism rs4833095 may contribute to the susceptibility of developing alopecia areata in the Korean population.
  • Further research is warranted to elucidate the role of TLR1 in the pathogenesis of AA.