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Extracorporeal photopheresis for paediatric patients experiencing graft-versus-host disease (GVHD)

Sergio Rutella1, Caterina Giovanna Valentini1, Stefano Ceccarelli1

  • 1Department of Paediatric Haematology/Oncology and Transfusion Medicine, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|May 1, 2014
PubMed

Insights

Extracorporeal photopheresis (ECP) treats various conditions, primarily graft-versus-host disease (GVHD) in children. This review highlights unique pediatric challenges and current clinical trials for ECP in treating pediatric GVHD.

Area of Science:

  • Immunology
  • Pediatric Hematology/Oncology
  • Transplantation

Background:

  • Extracorporeal photopheresis (ECP) is an established therapy for adult conditions including cutaneous T-cell lymphoma, graft-versus-host disease (GVHD), and transplant rejection.
  • In pediatric populations, ECP is predominantly utilized for managing GVHD.
  • Pediatric patients present unique physiological and size-related challenges for ECP administration.

Purpose of the Study:

  • To review current clinical trials involving ECP for pediatric GVHD.
  • To emphasize the technical and clinical considerations specific to applying ECP in children.

Main Methods:

  • Review of current clinical trials focusing on ECP in pediatric GVHD.
  • Analysis of technical and clinical challenges encountered in pediatric ECP.

Main Results:

  • GVHD is the primary indication for ECP in children.
  • Pediatric ECP requires adaptations due to patient size and physiology.
  • Ongoing clinical trials are exploring ECP efficacy and safety in pediatric GVHD.

Conclusions:

  • ECP is a crucial therapy for pediatric GVHD.
  • Addressing pediatric-specific challenges is essential for optimizing ECP outcomes.
  • Further research through clinical trials is needed to refine ECP protocols for children.

Keywords:
Childhood leukemiaGraft-versus-host diseasePhotopheresisSolid organ transplantation.Stem cell transplantation

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