Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

32
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
32
Renal Corpuscle01:20

Renal Corpuscle

8.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.4K
Nephrons01:10

Nephrons

8.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.2K
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion01:22

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

2.4K
The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...
2.4K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

5.9K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.9K
Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

2.1K
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury.

JCI insight·2025
Same author

Novel Role of Tryptophan Metabolic Pathway in Mediating Peroxisomal Dysfunction in High-Dose Voclosporin-Induced Acute Kidney Injury.

Journal of the American Society of Nephrology : JASN·2025
Same author

Assays to enhance metabolic phenotyping in the kidney.

American journal of physiology. Renal physiology·2025
Same author

Resazurin dye is an in vivo sensor of kidney tubular function.

Kidney international·2024
Same author

Energy Metabolism Dysregulation in Chronic Kidney Disease.

Kidney360·2023
Same author

Reprogramming of Energy Metabolism in Kidney Disease.

Nephron·2022

Related Experiment Video

Updated: Apr 30, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

798

Glomerular and tubular function in the diabetic kidney.

Roland C Blantz1, Prabhleen Singh1

  • 1Division of Nephrology-Hypertension, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, CA.

Advances in Chronic Kidney Disease
|May 1, 2014
PubMed
Summary

Diabetic nephropathy, a leading cause of kidney failure, involves early kidney changes like hypertrophy and hyperfiltration. Understanding these early diabetic kidney alterations is crucial for developing new treatments.

Keywords:
DiabetesGlomerular FiltrationSalt SensitivityTubular Reabsorption

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

21.0K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.7K

Related Experiment Videos

Last Updated: Apr 30, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

798
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

21.0K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.7K

Area of Science:

  • Nephrology
  • Endocrinology
  • Diabetology

Background:

  • Diabetic nephropathy is a major cause of end-stage renal disease.
  • Early structural and functional kidney changes in diabetes significantly impact disease progression.
  • Understanding these early mechanisms is vital for developing effective therapeutic strategies.

Purpose of the Study:

  • To focus on the early physiological changes in diabetic nephropathy.
  • To discuss primary and secondary mechanisms driving these alterations.
  • To enhance understanding of kidney function changes in early diabetes.

Main Methods:

  • Review of early physiological changes in diabetic nephropathy.
  • Discussion of primary and secondary mechanisms.
  • Analysis of alterations in glomerular and tubular function sensitivity to salt intake.

Main Results:

  • Early diabetic nephropathy is characterized by renal hypertrophy and hyperfiltration.
  • Proximal tubular hyperreabsorption is a distinctive feature.
  • Altered sensitivity of kidney function to dietary salt intake is observed.

Conclusions:

  • Early detection and understanding of diabetic kidney changes are critical.
  • Mechanisms underlying renal hypertrophy, hyperfiltration, and altered salt sensitivity require further investigation.
  • Targeting these early changes may offer new therapeutic avenues for diabetic nephropathy.