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Methylphenidate-risperidone combination in child psychiatry: A retrospective analysis of 44 cases

H Javelot1, C Glay-Ribau2, F Ligier3

  • 1Centre psychothérapeutique de Nancy-Laxou, 54520 Laxou, France; Service de psychiatrie de l'enfant et de l'adolescent, hôpital d'enfants, 54500 Vandœuvre-lès-Nancy, France; ETAP - neuropsychopharmacology department, 54500 Vandœuvre-lès-Nancy, France; Psychiatry II and Inserm unit 1114, university hospital of Strasbourg, 67000 Strasbourg, France; Clinical pharmacy service, établissement public de santé Alsace Nord, 67170 Brumath, France.

Annales Pharmaceutiques Francaises
|May 1, 2014
PubMed

Insights

Methylphenidate-risperidone combination therapy effectively reduced ADHD, conduct, sleep, and anxiety symptoms in children. While side effects like tachycardia and dyskinesia were noted, the overall benefit-risk ratio appears favorable for many young patients.

Area of Science:

  • Child and Adolescent Psychiatry
  • Pharmacology
  • Neurodevelopmental Disorders

Background:

  • Psychostimulant-antipsychotic combinations are common in child psychiatry but underreported.
  • Limited literature exists on methylphenidate-risperidone (MPH-RIS) bitherapy in pediatric populations.

Purpose of the Study:

  • To evaluate the efficacy and safety of MPH-RIS bitherapy in children.
  • To assess the impact of this combination on ADHD, conduct disorder, sleep, and anxiety symptoms.

Main Methods:

  • Retrospective study of 44 children treated with MPH-RIS bitherapy.
  • Analysis of children with comorbid Attention Deficit Hyperactivity Disorder (ADHD).

Main Results:

  • Over 60% of patients showed decreased ADHD, conduct, sleep, and anxiety symptoms.
  • Observed compensatory effects on weight gain (70%) and appetite (50%).
  • Rare instances of tachycardia (3 cases) and one case of dyskinesia were reported.

Conclusions:

  • MPH-RIS bitherapy demonstrates significant efficacy in children with ADHD and conduct disorder.
  • Tolerance issues may arise, but the benefit-risk profile is favorable for select pediatric cases.
Abstract

Keywords:
Associations psychostimulant-antipsychotiqueAttention deficit hyperactivity disorderChild psychiatryMethylphenidateMéthylphénidatePsychiatrie de l’enfantPsychotimulant-antipyschotic combinationsRisperidoneRispéridoneTrouble déficitaire de l’attention avec hyperactivité

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