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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

4.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K
Notch Signaling Pathway03:14

Notch Signaling Pathway

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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
1.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Related Experiment Video

Updated: Apr 30, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Oncogenic programmes and Notch activity: an 'organized crime'?

Maria Dominguez1

  • 1Instituto de Neurociencias, CSIC-UMH, Alicante, Spain.

Seminars in Cell & Developmental Biology
|May 1, 2014
PubMed
Summary
This summary is machine-generated.

Notch signaling impacts cancer development. Research in fruit flies reveals Notch

Keywords:
CancerDrosophilaNotch

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Area of Science:

  • Oncology
  • Developmental Biology
  • Genetics

Background:

  • Aberrant Notch signaling is implicated in various cancer hallmarks, including proliferation, survival, and metastasis.
  • Identifying Notch pathway partners in cancer is crucial for understanding its oncogenic roles.

Purpose of the Study:

  • To investigate the role of Notch signaling in cancer using Drosophila melanogaster as a model organism.
  • To identify novel Notch pathway interactions and partners involved in oncogenesis.

Main Methods:

  • Utilized the fruit fly Drosophila melanogaster, a cost-effective model with powerful genetic tools.
  • Screened for mutations affecting tumor formation and metastasis in the fly eye, a non-vital organ.
  • Leveraged the fly eye's structure for large-scale genetic screens and functional studies.

Main Results:

  • Demonstrated that Notch's oncogenic potential arises from cooperation with other oncogenes, not solely increased signaling.
  • Identified previously unknown partnerships between Notch and other cancer-related genes.
  • Uncovered unforeseen Notch partners contributing to cancer development.

Conclusions:

  • Notch signaling drives cancer through collaborative interactions with oncogenes.
  • Drosophila melanogaster is an effective model for discovering cancer genes and understanding complex signaling networks.
  • Understanding these partnerships is key to developing targeted cancer therapies.