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Updated: Apr 30, 2026
Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
Published on: January 17, 2025
[In vitro effect of psychotropic drugs on the activity of leukocyte elastase]
Objective:
To investigate the effect of the neuroleptic aminazine (chlorpromazine) and the antidepressant melipramine on the activity of leukocyte elastase (LE).
Methods:
The LE activity was measured on a spectrophotometer. Different doses of aminazine and melipramine in terms of therapeutic doses were added to the pooled blood serum sampled from 7 healthy people.
Results:
Aminazine and melipramine inhibited the LE activity.
Conclusions:
The dose-dependent inhibiting effect of aminazine and melipramine was shown.
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