Mucosal lichen planus: an evidence-based treatment update

Area of Science:

• Dermatology
• Oral Medicine
• Gastroenterology

Background:

• Mucosal lichen planus (MLP) is a chronic condition presenting significant therapeutic challenges.
• Effective management is crucial for patient comfort, quality of life, and clinical outcomes.
• Current literature lacks a definitive primary treatment modality for MLP.

Purpose of the Study:

• To systematically review the literature on the effectiveness of various treatment modalities for MLP.

Main Methods:

• Searched multiple databases (PubMed, EMBASE, Cochrane) for randomized controlled trials and systematic reviews.
• Included studies focused on mucosal lichen planus treatments.
• Meta-analysis was conducted where feasible.

Main Results:

• Topical corticosteroids (betamethasone valerate, clobetasol-17-propionate, fluocinonide) demonstrated effectiveness against placebo for oral lichen planus (OLP).
• Calcineurin inhibitors and topical retinoids were identified as beneficial options.
• The review excluded therapies with lower levels of evidence.

Conclusions:

• Topical corticosteroids are considered the primary therapy for OLP.
• There is a need for more high-quality evidence regarding the treatment of lichen planus.