Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

219
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
219
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

2.0K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
2.0K
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

90
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
90
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

295
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
295

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors for an infection with <i>Coxiella burnetii</i> in German sheep flocks.

Epidemiology and infection·2020
Same author

Health status of free-ranging ring-necked pheasant chicks (Phasianus colchicus) in North-Western Germany.

PloS one·2020
Same author

Prevalence of <i>Coxiella burnetii</i> in German sheep flocks and evaluation of a novel approach to detect an infection via preputial swabs at herd-level - ERRATUM.

Epidemiology and infection·2020
Same author

Investigation into diseases in free-ranging ring-necked pheasants (<i>Phasianus colchicus</i>) in northwestern Germany during population decline with special reference to infectious pathogens.

European journal of wildlife research·2020
Same author

Prevalence of <i>Coxiella burnetii</i> in German sheep flocks and evaluation of a novel approach to detect an infection via preputial swabs at herd-level.

Epidemiology and infection·2020
Same author

Danish Prostate Cancer Registry - methodology and early results from a novel national database.

Clinical epidemiology·2016
Same journal

[The progress of participation research. A sociological analysis of its institutionalization].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Applying the German demand planning guideline to maternity care provision: regional and socioeconomic disparities].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Medical aids for children and adolescents following the legislative change-a status report].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Doping: caught between fraud, health protection, and responsibility].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Aging with intellectual and developmental disabilities or severe multiple disabilities-health, participation, and care in later life].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Sexual self-determination and disability: 10 years of the ReWiKs project-dynamics and findings].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Bioassays for Monitoring Insecticide Resistance
06:30

Bioassays for Monitoring Insecticide Resistance

Published on: December 30, 2010

34.3K

[Rodenticide resistance and consequences].

A Esther1, S Endepols, J Freise

  • 1Bundesforschungsinstitut für Kulturpflanzen, Institut für Pflanzenschutz in Gartenbau und Forst, Wirbeltierforschung, Julius Kühn-Institut (JKI), Toppheideweg 88, 48161, Münster, Deutschland, alexandra.esther@jki.bund.de.

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
|May 1, 2014
PubMed
Summary
This summary is machine-generated.

Rodenticide resistance in Norway rats and house mice is driven by VKORC1 gene mutations. This genetic resistance impacts rodent control, necessitating strategic use of potent anticoagulants where resistance is confirmed.

More Related Videos

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

8.5K
Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
09:32

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

16.5K

Related Experiment Videos

Last Updated: Apr 30, 2026

Bioassays for Monitoring Insecticide Resistance
06:30

Bioassays for Monitoring Insecticide Resistance

Published on: December 30, 2010

34.3K
Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

8.5K
Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
09:32

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

16.5K

Area of Science:

  • Genetics
  • Toxicology
  • Pest Management

Context:

  • Rodenticide resistance, first identified in 1958, poses significant challenges.
  • Genetic mutations in the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene are the primary cause.
  • Resistant Norway rats (Tyr139Cys genotype) are prevalent in northwest Germany.

Purpose:

  • To investigate the genetic basis of rodenticide resistance in Norway rats and house mice.
  • To understand the distribution and impact of specific VKORC1 variants on rodent populations in Germany.
  • To inform effective rodent management strategies in the face of widespread resistance.

Summary:

  • Specific VKORC1 gene polymorphisms, such as Tyr139Cys in Norway rats and multiple variants (Tyr139Cys, Leu128Ser, spretus type) in house mice, confer resistance to anticoagulant rodenticides.
  • First-generation anticoagulants and some second-generation compounds are ineffective against resistant populations.
  • Potent second-generation anticoagulants (brodifacoum, flocoumafen, difethialone) are recommended for confirmed resistant populations, while less toxic options should be used elsewhere to minimize environmental risks.

Impact:

  • Reduced efficacy of common rodent control methods, impacting stored product protection, hygiene, and animal health.
  • Necessitates the use of more toxic or persistent rodenticides in specific cases, increasing environmental concerns.
  • Highlights the need for further research into VKORC1 polymorphism combinations, resistance spread, and management strategies to mitigate resistance development.