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Relationship between serum creatinine and obesity in children in Xinjiang, China

X-M Li1, Y-T Ma1, X Xie1

  • 1Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Genetics and Molecular Research : GMR
|May 1, 2014
PubMed

Insights

Obesity is linked to higher serum creatinine levels in children over 10 years old in Xinjiang, China. Maintaining a healthy weight is crucial for protecting kidney function in this age group.

Area of Science:

  • Pediatrics
  • Nephrology
  • Public Health

Background:

  • Serum creatinine levels are important indicators of kidney function.
  • Childhood obesity rates are rising globally, necessitating studies on associated health risks.
  • Understanding the relationship between body mass index and serum creatinine in children is vital for early detection of renal issues.

Purpose of the Study:

  • To investigate the association between serum creatinine and body mass index (BMI) in a pediatric population in Xinjiang, China.
  • To determine if obesity is an independent risk factor for elevated serum creatinine in children.
  • To provide evidence for weight management strategies aimed at preserving renal health in children.

Main Methods:

  • A stratified sampling method was employed to recruit 5222 children aged 6-17 years from three regions in Xinjiang.
  • Serum creatinine levels were measured using an enzymatic method.
  • Statistical analyses, including correlation and multivariate regression, were performed to assess the relationship between serum creatinine and BMI, adjusting for potential confounders.

Main Results:

  • Serum creatinine levels increased with age across different pediatric groups.
  • A significant positive correlation was observed between serum creatinine and BMI in children older than 10 years (r values ranging from 0.016 to 0.380, P < 0.05).
  • Multivariate regression analysis confirmed that obesity is an independent risk factor for elevated serum creatinine in children over 10 years old (β values ranging from 0.041 to 0.171, P < 0.05).

Conclusions:

  • Obesity is identified as an independent risk factor for increased serum creatinine levels in children aged 10 years and older.
  • Weight control and management are essential for the protection of renal function in children, particularly those who are overweight or obese.
  • These findings highlight the importance of monitoring BMI and renal health indicators in pediatric populations to prevent long-term kidney complications.

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