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Interferon-containing and interferon-free HCV therapy for HIV-infected patients

Mark S Sulkowski1

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Seminars in Liver Disease
|May 1, 2014
PubMed

Insights

Treating hepatitis C virus (HCV) infection in patients with human immunodeficiency virus (HIV) improves outcomes. Newer interferon-free treatments offer greater efficacy and access for coinfected individuals.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Virology

Background:

  • Coinfection with hepatitis C virus (HCV) significantly increases morbidity and mortality in human immunodeficiency virus (HIV)-infected patients.
  • Sustained virologic response (SVR) in HCV infection is linked to reduced liver disease progression and improved survival in coinfected individuals.
  • Traditional interferon-α (INFα)-based HCV treatments had limitations, including contraindications and suboptimal SVR rates.

Purpose of the Study:

  • To review the impact of HCV treatment on outcomes in coinfected patients.
  • To highlight advancements in HCV treatment efficacy and accessibility for HIV-coinfected individuals.

Main Methods:

  • Review of existing literature on HCV treatment in HIV-coinfected populations.
  • Analysis of treatment outcomes associated with INFα-based regimens and direct-acting antivirals (DAAs).

Main Results:

  • HCV treatment leading to SVR significantly decreases the risk of end-stage liver disease and hepatocellular carcinoma.
  • Efficacy of HCV treatment has improved with the integration of DAAs into INFα-based regimens since 2011.
  • Interferon-free oral HCV treatments are anticipated to further enhance efficacy and treatment accessibility.

Conclusions:

  • Effective HCV treatment is crucial for improving long-term outcomes in HIV-coinfected patients.
  • The development of interferon-free DAAs represents a significant advancement in managing HCV/HIV coinfection.
  • Future oral HCV therapies hold promise for broader treatment access and improved patient management.

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