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Updated: Jan 8, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
[Determination of R(-)- isomer in repaglinide tablets by capillary electrophoresis]
Xiao-wei Yuan1, Jia-yi Sun1, Shi-zhuo Wang1
1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Objective:
To develop a capillary electrophoresis system for enantiomeric impurity test of repaglinide.
Methods:
An uncoated fused silica capillary (50 μm×50 cm, with an effective length of 41 cm) was used. The running buffer was composed of 30 mmol/L NaH2PO4 and 5 mg/ml carboxymethyl-β-cyclodextrin(pH 3.5).
Results:
Linear range was 2.00-80.00 μg/ml (correlation coefficient was 0.9993). The average recovery rate was 92.5% to 105.0%.
Conclusion:
The method is simple, accurate and sensitive and it can be used for determination of enantiomeric impurities in repaglinide tablet.
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