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Updated: Apr 30, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Association between parathyroid hormone levels and inflammatory markers among US adults
Shih-Ping Cheng1, Chien-Liang Liu2, Tsang-Pai Liu2
1Department of Surgery, Mackay Memorial Hospital and Mackay Medical College, 92 Chung-Shan North Road, Section 2, Taipei 10449, Taiwan ; Mackay Junior College of Medicine, Nursing and Management, 92 Shengjing Road, Taipei 11260, Taiwan ; Department of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan.
Background And Aims:
High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults.
Materials And Methods:
Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein (CRP), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) levels with weighted linear regression. Additionally, we examined the relation with increased modified Glasgow Prognostic Score (mGPS) by using weighted logistic regression.
Results:
CRP, RDW, and PLR values increased with increasing serum PTH concentration. After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories (all P < 0.001), while PLR marginally increased (P = 0.190 and P = 0.095 using PTH as a categorical and continuous variable, resp.). The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously.
Conclusion:
These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population. The casual relationship between PTH levels and inflammation remains to be elucidated.
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