Related Experiment Video
Updated: Apr 30, 2026
06:24
Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
Published on: July 8, 2025
1.2K
Magnesium: potential roles in neurovascular disease
Jason J Chang1, William J Mack2, Jeffrey L Saver3
1Department of Neurology, University of Southern California , Los Angeles, CA , USA.
Frontiers in Neurology
|May 1, 2014
Summary
Magnesium shows promise for neuroprotection in specific procedures like cardiac surgery and for pre-term infants. However, its effectiveness in stroke and hemorrhage remains uncertain due to administration timing.
Area of Science:
- Neuroscience
- Pharmacology
- Critical Care Medicine
Background:
- Magnesium therapy is explored for neuroprotection in various conditions.
- Cerebrovascular diseases may potentially benefit from magnesium's properties.
Purpose of the Study:
- To review current research on magnesium's role in neurovascular diseases.
- To assess magnesium's efficacy and safety as a neuroprotectant.
Main Methods:
- Comprehensive literature search of PubMed database.
- Inclusion of basic science, translational, meta-analysis, and clinical studies.
Main Results:
- Magnesium did not improve outcomes in ischemic stroke.
- Limited data exists for intracerebral hemorrhage; preliminary subarachnoid hemorrhage studies showed no significant difference from placebo.
- Trends suggest benefit in global ischemia post-cardiac arrest.
- Strongest evidence for neuroprotection in pre-term infants and during cardiac bypass/carotid endarterectomy.
- Magnesium demonstrated an excellent safety profile.
Conclusions:
- Magnesium is safe and easy to administer.
- Promising neuroprotective potential in cardiac surgery, carotid endarterectomy, and pre-term infant hypoxia.
- Efficacy in stroke, intracerebral hemorrhage, and subarachnoid hemorrhage is unclear, possibly due to delayed administration.
- Further trials focusing on early administration are needed to clarify magnesium's role.
Keywords:
all cerebrovascular disease/strokeintracerebral hemorrhagemagnesiumneuroprotectionsubarachnoid hemorrhageMore Related Videos
Related Concept Videos
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
4.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.6K
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
1.2K
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.2K
00:49The Blood-brain Barrier
47.3K
Overview
47.3K
01:25Secondary Spinal Cord Injury llI: Pathophysiology
52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52
01:19Multiple Sclerosis l: Introduction
20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20
01:23Role of Neurotransmitters in Memory
2.8K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.8K