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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Related Experiment Video

Updated: Apr 30, 2026

An Ex vivo Culture System to Study Thyroid Development
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An Ex vivo Culture System to Study Thyroid Development

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Thyroid regeneration: how stem cells play a role?

Shioko Kimura1

  • 1Laboratory of Metabolism, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA.

Frontiers in Endocrinology
|May 1, 2014
PubMed
Summary
This summary is machine-generated.

Adult thyroid stem cells are crucial for tissue repair. Understanding their role in regeneration may illuminate the nature of thyroid cancer stem cells and related diseases.

Keywords:
OCT4 expressionadult-resident thyroid stem/progenitor cellspartial thyroidectomyside populationsolid cell nestsphere/spheroid cultureultimobranchial body cyst

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Area of Science:

  • Stem cell biology
  • Endocrinology
  • Oncology

Background:

  • Stem cells drive tissue regeneration and repair after injury.
  • Dysregulation of tissue regeneration is linked to pathologies, including cancer.
  • The precise nature of cancer stem cells and their relationship to normal stem cells, especially in the thyroid, remains poorly understood.

Purpose of the Study:

  • To review the current understanding of adult thyroid stem/progenitor cells.
  • To emphasize the contribution of these cells to thyroid regeneration.
  • To bridge the knowledge gap between normal and cancer stem cells in the thyroid.

Main Methods:

  • Literature review of studies on adult thyroid stem/progenitor cells.
  • Analysis of mechanisms involved in thyroid regeneration.
  • Exploration of the potential link between normal and cancer stem cells in thyroid pathogenesis.

Main Results:

  • Thyroid stem/progenitor cells play a key role in tissue repair and regeneration.
  • Understanding normal stem cell function is essential for deciphering cancer stem cell behavior.
  • A gap exists in knowledge regarding the relationship between normal and thyroid cancer stem cells.

Conclusions:

  • Further research into adult thyroid stem/progenitor cells and their regenerative functions is critical.
  • This understanding may elucidate the origins and behavior of thyroid cancer stem cells.
  • Investigating thyroid regeneration can provide insights into thyroid disease pathogenesis.