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Related Experiment Video

Updated: Apr 30, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.4K

Mouse models to study dengue virus immunology and pathogenesis.

Raphaël M Zellweger1, Sujan Shresta1

  • 1Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology , La Jolla, CA , USA.

Frontiers in Immunology
|May 1, 2014
PubMed
Summary
This summary is machine-generated.

Developing effective mouse models for dengue virus (DENV) infection is difficult. However, these models offer valuable insights into DENV pathogenesis and potential treatments, complementing human studies.

Keywords:
adaptive immunityantibody-dependent enhancementdenguemouse modelsvaccines

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Area of Science:

  • Virology
  • Immunology
  • Animal Models

Background:

  • Dengue virus (DENV) infection is challenging to model in immunocompetent mice.
  • Clinical DENV isolates show limited replication and pathology in standard mouse models.
  • Existing research often relies on immunocompromised mice or adapted viral strains.

Purpose of the Study:

  • To review the strengths and limitations of current mouse models for studying dengue disease.
  • To highlight the utility of mouse models for experimental hypothesis testing and pre-clinical research.
  • To discuss the extrapolation of findings from mouse models to human DENV infections.

Main Methods:

  • Review of existing literature on murine models of DENV infection.
  • Discussion of experimental parameters and immunological investigations possible in mouse models.
  • Analysis of the application of mouse models in anti-viral drug and vaccine development.

Main Results:

  • Mouse models provide well-defined experimental conditions for studying DENV.
  • They enable the investigation of immune system components in protection and pathogenesis.
  • Mouse models are instrumental in pre-clinical testing of therapeutics and vaccines.

Conclusions:

  • Mouse models are valuable for understanding DENV, complementing in vitro and epidemiological data.
  • Findings from mouse studies require cautious extrapolation to human dengue.
  • Further research in mouse models can identify new areas for human study.