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Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

28
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
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Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

42
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
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Isolated hepatic sarcoidosis.

Ivana Jovicić, Duaan Dj Popović, Ljubisa Toncev

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    Isolated hepatic sarcoidosis, a rare condition, presents with liver and spleen enlargement. Prompt diagnosis via liver biopsy and corticosteroid treatment led to significant patient improvement.

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    Area of Science:

    • Hepatology
    • Immunology
    • Granulomatous diseases

    Background:

    • Sarcoidosis is a multisystem granulomatous disease with unknown cause.
    • Hepatic granulomas are common in systemic sarcoidosis, but isolated liver sarcoidosis is rare.
    • Clinical manifestations range from asymptomatic to severe, with diagnosis confirmed by liver biopsy.

    Observation:

    • A 69-year-old male presented with abdominal swelling and pain.
    • Laboratory results revealed cholestasis, pancytopenia, and elevated angiotensin-converting enzyme.
    • Abdominal imaging showed liver cirrhosis, splenomegaly, and ascites.

    Findings:

    • Histopathological examination of liver biopsy confirmed isolated hepatic sarcoidosis.
    • Treatment with corticosteroids resulted in complete symptom resolution after 18 months.
    • Biochemical and clinical improvements were observed post-treatment.

    Implications:

    • Isolated hepatic sarcoidosis must be considered in patients with unexplained hepatosplenomegaly and abnormal liver function tests.
    • Early diagnosis and appropriate corticosteroid therapy are crucial for favorable patient outcomes.
    • This case highlights the importance of considering rare presentations of sarcoidosis for effective management.