[Progress in methodology of establishing physiologically based pharmacokinetic models]

Area of Science:

• Pharmacokinetics and Drug Metabolism
• Computational Biology and Bioinformatics
• Pharmaceutical Sciences

Background:

• Physiologically based pharmacokinetic (PBPK) models are mechanistic mathematical tools simulating drug ADME.
• PBPK modeling is gaining traction in pharmaceutical research and development.
• Understanding PBPK model establishment and application is crucial for drug discovery.

Purpose of the Study:

• To review recent advancements in establishing PBPK models.
• To discuss the application significance, challenges, and future of PBPK models in pharmaceuticals.
• To provide a comprehensive overview of PBPK model development procedures.

Main Methods:

• Review of recent literature on PBPK model development.
• Analysis of procedures for PBPK model structure and tissue specification.
• Examination of equation formulation, parameterization, simulation, and evaluation techniques.

Main Results:

• Recent advances in PBPK model structure specification.
• Detailed discussion on tissue modeling and equation writing.
• Insights into parameter setting, simulation, and model evaluation methodologies.

Conclusions:

• PBPK models are vital mechanistic tools for simulating drug absorption, distribution, metabolism, and excretion (ADME).
• The review highlights key steps in establishing PBPK models, from structure to evaluation.
• Future directions and challenges in pharmaceutical PBPK applications are discussed.