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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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Post stroke depression.
Summary
Depression after stroke is more common in younger women and those with left-hemisphere strokes and higher disability. This impacts post-stroke quality of life.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Comorbidity of depression and stroke significantly reduces post-stroke quality of life.
- Stroke sequelae influence quality of life and the occurrence of post-stroke depression.
- Investigated depression occurrence in stroke patients using the Hamilton scale and disability using the NIHSS scale.
Purpose of the Study:
- Comparative analysis of depression after stroke based on gender, age, lesion side, and neurological deficit severity.
- To understand the relationship between stroke characteristics and depression.
- To identify risk factors for post-stroke depression.
Main Methods:
- Study included 210 stroke patients (105 male, 105 female) treated at the Neurology Clinic, Clinical Center of Sarajevo University.
- Mean patient age was 67.12 ± 9.5 years; 65% had ischemic stroke.
- Depression assessed by Hamilton scale; disability by NIHSS scale.
Main Results:
- Depression was more prevalent in younger patients (52-60 years) (39.2%) compared to older patients (61-70 years) (32%).
- Significantly more women (63.8%) experienced depression compared to men (27.2%) (p=0.00019).
- Depression was more frequent in patients with stroke in the left hemisphere medial localization (63%) and higher NIHSS scores (average 16.07).
Conclusions:
- Post-stroke depression is more frequent in younger patients.
- Female patients exhibit higher rates of depression post-stroke.
- Higher disability scores and left medial hemisphere strokes are associated with increased depression prevalence.
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