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Updated: Apr 30, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Synthesis of carbohydrate methyl phosphoramidates
Roger A Ashmus1, Todd L Lowary
1Alberta Glycomics Centre and Department of Chemistry, The University of Alberta , Gunning-Lumieux Chemistry Centre, Edmonton, Alberta T6G 2G2, Canada.
Abstract:
A two-step route for introducing methyl phosphoramidate moieties onto carbohydrates is reported. The approach uses methyl pivolyl H-phosphonate as the phosphorylating reagent to produce an isolable carbohydrate H-phosphonate intermediate that is then oxidized by a Todd-Atherton reaction. The stability of the product methyl phosphoramidates was subsequently evaluated using various deprotection strategies.
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