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Emergence delirium in children: an update
Souhayl Dahmani1, Honorine Delivet, Julie Hilly
1aDepartment of Anesthesiology and Intensive Care, Robert Debré University Hospital bParis Diderot University, Paris VII, Paris Sorbonne Cité cINSERM UMR 676, Robert Debré University Hospital dDepartment of Pain Management, Robert Debré University eParis Descartes University, Paris V, Paris Sorbonne Cité, Paris, France.
Insights
Emergence delirium in children, a common anesthesia complication, can be prevented by managing preoperative anxiety and pain. Alpha-2 agonists like dexmedetomidine are recommended for treatment due to their benefits.
Area of Science:
- Pediatric Anesthesiology
- Neuroscience
- Pharmacology
Background:
- Emergence delirium (ED) is a common yet poorly understood complication following pediatric anesthesia.
- While fast-acting volatile anesthetics are suspected, evidence linking them to ED is limited.
- This review synthesizes recent research on ED in children.
Purpose of the Study:
- To review recent findings on emergence delirium in pediatric anesthesia.
- To explore the causes, prevention, and treatment of ED.
- To highlight the link between ED and long-term cognitive complications.
Main Methods:
- Literature review of recent studies on emergence delirium in children.
- Analysis of factors contributing to ED, including anesthetic agents and patient characteristics.
- Evaluation of preventive and therapeutic strategies.
Main Results:
- ED typically affects preschool children after sevoflurane or desflurane anesthesia, presenting as intense anxiety.
- Both painful and non-painful procedures can trigger ED.
- Prevention involves managing preoperative anxiety, ensuring adequate analgesia, and using intraoperative sedatives (e.g., ketamine, dexmedetomidine).
- Treatment for severe agitation may involve propofol, opioids, or dexmedetomidine, with dexmedetomidine favored for its additional benefits.
- ED shares risk factors with long-term cognitive issues, necessitating parental awareness.
Conclusions:
- Emergence delirium is a frequent and preventable complication in pediatric anesthesia.
- Effective strategies include proactive pain management and the use of alpha-2 agonists.
- Parental education regarding ED and potential long-term behavioral changes is crucial.
Purpose Of Review:
Emergence delirium in children is still considered as a mysterious complication occurring after pediatric anesthesia. Although the pharmacology of fast-acting volatile agent is highly suspected in the genesis of this complication, no strong evidence has been published to support this hypothesis. This review summarizes the recent findings concerning this complication.
Recent Findings:
Emergence delirium occurs typically in preschool children, with a high intensity of anxiety, after sevoflurane or desflurane anesthesia. In addition, although pain has been suspected in the genesis of this complication, emergence delirium has also been described after nonpainful procedure (imaging). Prevention of this complication relies on preventing preoperative anxiety (using premedication and psychological approaches), providing a sufficient analgesia (either systemically or by regional analgesia) and administering intraoperative sedative agents such as ketamine, clonidine, dexmedetomidine, gabapentine, midazolam, magnesium, hydroxyzine, midazolam and dexamethasone. Treatment of emergence delirium should be pharmacological when facing intense agitation with self-injury risks. This could be achieved using propofol, opioid agents or dexmedetomidine. As a result of the delayed discharge from a postoperative care unit associated with these agents, dexmedetomidine should be favored because of its analgesic and postoperative nausea and vomiting preventive effects. As emergence delirium shares many risk factors with long-lasting cognitive complications such as postoperative maladaptative behavioral changes, letting parents know about these complications is requested.
Summary:
Emergence delirium in children is a frequent but preventable complication. Strategies for prevention and therapy include particularly pain management and medication with alpha-2 agonists.
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