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Related Experiment Video

Updated: Apr 30, 2026

Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery
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Multifocal Necrotizing Chorioretinitis Following Phacoemulsification Surgery.

Imran H Yusuf1, Shahrnaz Izadi, Timothy H M Fung

  • 1Department of Ophthalmology, Oxford Eye Hospital, Headley Way, Headington , Oxford , OX3 9DU United Kingdom .

Ocular Immunology and Inflammation
|May 3, 2014
PubMed
Summary

Toxoplasma chorioretinitis can present atypically in elderly, immunosuppressed patients, even after cataract surgery. Early diagnosis is challenging, highlighting the importance of vitreous biopsy for identifying infectious posterior uveitis.

Keywords:
ImmunosupressionToxoplasma chorioretinitisinvestigationphacoemulsificationposterior uveitispostoperative iritistoxoplasmosis

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Area of Science:

  • Ophthalmology
  • Infectious Diseases

Background:

  • Toxoplasma chorioretinitis is a major cause of infectious posterior uveitis globally.
  • Elderly and immunosuppressed individuals are at higher risk for atypical presentations.

Observation:

  • An 81-year-old male with hypernephroma and rheumatoid arthritis, on immunosuppressive therapy, presented with atypical Toxoplasma chorioretinitis post-cataract surgery.
  • Initial symptoms mimicked acute retinal necrosis and cytomegalovirus retinitis.

Findings:

  • Toxoplasma chorioretinitis was confirmed via vitreous biopsy 11 months after symptom onset.
  • The patient developed a secondary rhegmatogenous retinal detachment, successfully treated with pars plana vitrectomy.

Implications:

  • Necrotizing chorioretinitis in immunocompromised or elderly patients can exhibit unusual phenotypes, complicating clinical diagnosis.
  • Vitreous PCR plays a crucial role in differentiating viral and Toxoplasma retinitis for effective management of infectious posterior uveitis.