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Updated: Apr 30, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

Graphene- and aptamer-based electrochemical biosensor.

Ke Xu¹, Xenia Meshik, Barbara M Nichols

¹Department of Electrical and Computer Engineering, University of Illinois, Chicago, IL 60607, USA.

|May 3, 2014

Summary

This summary is machine-generated.

This study presents a graphene and aptamer sensor for detecting lead and potassium ions. The sensor monitors electrical current changes caused by ion binding to aptamers, enabling ion concentration measurement.

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Area of Science:

Nanotechnology
Biosensors
Electrochemistry

Background:

Graphene-based sensors offer high surface area and conductivity.
Aptamers provide specific molecular recognition capabilities.
Field-effect transistors (FETs) are sensitive electronic devices.

Purpose of the Study:

To develop and evaluate a graphene- and aptamer-based FET-like sensor.
To detect lead (Pb2+) and potassium (K+) ions.
To correlate sensor response with ion concentration.

Main Methods:

Fabrication of a sensor using a graphene-covered Si/SiO2 wafer.
Immobilization of thrombin binding aptamer (TBA) and methylene blue (MB).
Measurement of device transfer curves and drain current (Id) at varying ion concentrations.

Main Results:

Sensor demonstrated ambipolar field effect.
Drain current (Id) decreased with increasing K+ and Pb2+ concentrations.
A negative shift in the Dirac voltage (VDirac) was observed with increased ion concentration.

Conclusions:

The developed FET-like sensor effectively detects K+ and Pb2+ ions.
The sensor's electrical response is sensitive to ion binding and concentration.
This aptasensor shows promise for electrochemical sensing applications.