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Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures
T Iida1, E Kobayashi, M Yoshida
1Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Japan.
The Journal of Antibiotics
|October 1, 1989
Abstract:
The structures of new antitumor antibiotics, calphostins (UCN-1028) A, B, C, D and I, which are specific and potent inhibitors of protein kinase C, were determined by spectral and chemical studies. All of the antibiotics have a 3,10-perylenequinone skeleton and calphostin D was revealed to be an antipode of isophleichrome.