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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Potential for layered double hydroxides-based, innovative drug delivery systems.

Kai Zhang1, Zhi Ping Xu2, Ji Lu3

  • 1School of Medical Science & Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD 4222, Australia. kai.zhang4@griffithuni.edu.au.

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Layered Double Hydroxides (LDHs) show promise as biocompatible nanoparticle drug carriers. They efficiently deliver various molecules, including genetic material, for therapeutic applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Layered Double Hydroxides (LDHs) are advanced nanomaterials with significant potential in drug delivery.
  • LDHs offer high drug loading capacity and protect therapeutic molecules from degradation.
  • Toxicological studies confirm LDHs' biocompatibility, outperforming other nanoparticles like silica and carbon nanotubes.

Purpose of the Study:

  • To review the progress and applications of LDHs as nanoparticle drug carriers.
  • To highlight the use of LDHs in delivering nucleotides, anti-inflammatory, and anti-cancer drugs.
  • To explore recent advancements and future prospects of LDHs in medical research.

Main Methods:

  • Review of existing literature on LDHs in drug delivery and gene therapy.
  • Analysis of co-precipitation and anion-exchange methods for drug loading.
  • Evaluation of toxicological data and biocompatibility studies.

Main Results:

  • LDHs effectively carry diverse biomolecules, including amino acids, peptides, ATPs, vitamins, polysaccharides, and nucleic acids.
  • LDHs have been successfully applied in gene delivery for targeting specific cells and organs.
  • Recent applications include anti-inflammatory and anti-cancer drug delivery systems.

Conclusions:

  • LDHs represent a promising platform for developing novel nano-drugs.
  • Further research into LDHs could lead to new clinical applications in gene therapy and targeted drug delivery.
  • The biocompatibility and efficiency of LDHs position them as a key material for future nanomedicine.