Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Apr 30, 2026

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Published on: August 7, 2011

Limited mouse necropsy.

Robert D Cardiff¹, Claramae H Miller, Robert J Munn

¹Center for Comparative Medicine and Center for Genomic Pathology, University of California, Davis, Davis, California 95616.

Cold Spring Harbor Protocols

|May 3, 2014

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Overexpression of TSG101 causes the development of adenosquamous mammary carcinoma.

Breast cancer research : BCR·2025

Same author

Nonlinear progression during the occult transition establishes cancer lethality.

Disease models & mechanisms·2025

Same author

Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.

bioRxiv : the preprint server for biology·2025

Same author

Nonlinear progression during the occult transition establishes cancer lethality.

bioRxiv : the preprint server for biology·2024

Same author

Editor's Note: Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model.

Cancer research·2023

Same author

Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism.

Molecular cancer research : MCR·2022

Same journal

High-Throughput Microbial Assay for Amino Acid Measurement in Ground Maize Seed Samples Utilizing Auxotrophic <i>E. coli</i>.

Cold Spring Harbor protocols·2025

Same journal

Grain Quality in Maize.

Cold Spring Harbor protocols·2025

Same journal

High-Throughput Assay for Measuring Phytate and Available Phosphorus in Ground Maize Seed Samples.

Cold Spring Harbor protocols·2025

Same journal

Functional Genomic Analysis of Transposon Insertion Mutant Maize Plants from the UniformMu National Public Resource.

Cold Spring Harbor protocols·2025

Same journal

The UniformMu National Public Resource: Transposon<i>-</i>Induced Mutant Seeds for Functional Genomics Studies in Maize.

Cold Spring Harbor protocols·2025

Same journal

Insights from the Study of B<i>-</i>Cell Epitopes of a Microbial Pathogen by Phage Display.

Cold Spring Harbor protocols·2025

See all related articles

A limited mouse necropsy protocol for thorax and abdomen examination is described. This method provides essential tissue and organ data for phenotype verification, complementing limited biopsy techniques.

Area of Science:

Veterinary Pathology
Laboratory Animal Science
Phenotyping

Background:

Accurate phenotype verification in research models often requires comprehensive tissue and organ examination.
Limited biopsy or surgical interventions may not provide sufficient data for complete analysis.
Necropsy offers a more thorough approach to data acquisition from animal models.

Purpose of the Study:

To describe a standardized protocol for a limited necropsy procedure in mice.
To facilitate the procurement of key thoracic and abdominal tissues and organs.
To support detailed phenotypic analysis in research studies.

Main Methods:

The protocol details a limited autopsy focusing exclusively on the thoracic and abdominal cavities.
Specific procedures for organ and tissue collection from these regions are outlined.

More Related Videos

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

Related Experiment Videos

Last Updated: Apr 30, 2026

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Published on: August 7, 2011

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

Emphasis is placed on careful dissection and preservation techniques.

Main Results:

The described limited necropsy allows for the systematic collection of essential organs and tissues.
This approach yields valuable data for phenotype verification.
The protocol is designed for efficiency and reproducibility.

Conclusions:

A limited mouse necropsy protocol focusing on the thorax and abdomen is feasible and valuable.
This method aids in comprehensive phenotype verification when full necropsy is not required.
The protocol serves as a practical guide for researchers needing specific organ data.