Related Experiment Video
Updated: Apr 30, 2026
10:03
Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
Published on: August 16, 2020
11.4K
Clinical correlations of microstructural changes in progressive supranuclear palsy
Alessandro Tessitore1, Alfonso Giordano2, Giuseppina Caiazzo3
1Department of Neurology, Second University of Naples, Naples, Italy.
Neurobiology of Aging
|May 3, 2014
Summary
Progressive supranuclear palsy (PSP) patients exhibit significant white matter damage. Fronto-cerebellar white matter loss correlates with executive cognitive deficits in PSP, suggesting cerebellar disconnection contributes to cognitive impairment.
Area of Science:
- Neuroscience
- Neurology
- Radiology
Background:
- Progressive supranuclear palsy (PSP) is characterized by severe white matter (WM) damage affecting supra and infratentorial regions.
- Previous studies indicate widespread WM abnormalities in PSP patients.
Purpose of the Study:
- To investigate the correlation between white matter integrity loss and clinical-cognitive features in PSP.
- To identify specific WM regions associated with cognitive decline in PSP.
Main Methods:
- Magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) with tract-based spatial statistics (TBSS) were employed.
- WM volume was analyzed in 18 PSP patients and 18 healthy controls (HCs).
- Detailed clinical and neuropsychological evaluations were performed on all participants.
Main Results:
- PSP patients demonstrated significant WM changes across supra and infratentorial areas compared to HCs.
- Affected regions included the corpus callosum, fornix, midbrain, and various fasciculi.
- A significant association was found between fronto-cerebellar WM loss and executive cognitive impairment in PSP.
Conclusions:
- Cognitive impairment in PSP may stem from both intrinsic and extrinsic frontal lobe dysfunction.
- Cerebellar disconnection is a likely contributor to the observed cognitive deficits in PSP.
- These findings support a neuroanatomical basis for cognitive decline in progressive supranuclear palsy.
Keywords:
Abnormal diffusivityCerebellar cognitive syndromeDiffusion tensor imagingMagnetic resonance imagingProgressive supranuclear palsyTract based spatial statisticsMore Related Videos
08:33Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
7.7K
08:29Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
Published on: December 18, 2016
13.9K
Related Concept Videos
01:23Alzheimer Disease ll: Pathophysiology
35
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
35
01:24Parkinson Disease ll: Pathophysiology
28
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
28
01:15Parkinson's Disease: Overview
2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
01:11Alterations in Muscle Tone lll
29
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
29
01:37Neural Regulation
34.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
34.8K
01:24Parkinson Disease l: Introduction
28
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
28