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Related Experiment Videos

Calgranulin expression in inflammatory dermatoses.

S E Kelly1, D B Jones, S Fleming

  • 1Department of Dermatology, University of Edinburgh, U.K.

The Journal of Pathology
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

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Calgranulins, calcium-binding proteins with cytokine activity, are expressed by skin keratinocytes in inflammatory dermatoses. This study investigated calgranulin expression in various skin conditions.

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Calgranulins are intracellular calcium-binding proteins.
  • They possess inflammatory cytokine activity.
  • Calgranulins consist of calgranulin A and B chains.

Purpose of the Study:

  • To investigate the expression of calgranulins in keratinocytes within inflammatory dermatoses.
  • To determine if calgranulin expression differs between lesional and non-lesional skin in these conditions.

Main Methods:

  • Utilized monoclonal antibodies (CF 145, CF 557, MAC 387) to detect calgranulin A, B, and combined forms.
  • Examined keratinocytes from normal skin and skin lesions of 52 patients with inflammatory dermatoses.

Main Results:

Related Experiment Videos

  • Normal skin keratinocytes did not express calgranulins.
  • Keratinocytes in lesional skin of inflammatory dermatoses consistently expressed both calgranulin A and B chains.
  • Non-lesional skin keratinocytes did not show calgranulin expression.

Conclusions:

  • Keratinocytes in inflammatory dermatoses express intracellular calcium-binding proteins with cytokine activity.
  • Calgranulin expression is localized to lesional skin in inflammatory dermatoses.