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Related Experiment Video

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

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Published on: February 19, 2016

Thermoresponsive layer-by-layer assemblies for nanoparticle-based drug delivery.

Jing Zhou¹, Michael V Pishko, Jodie L Lutkenhaus

¹Department of Materials Science and Engineering, Texas A&M University , College Station, Texas 77843-3003, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|May 3, 2014

Summary

This study developed thermoresponsive layer-by-layer (LbL) capsules for controlled drug delivery. By tuning the LbL assembly, dexamethasone release can be controlled by temperature, offering a promising therapeutic approach.

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Layer-by-layer (LbL) capsules offer tunable properties for drug delivery.
Achieving sustained and controlled drug release from LbL systems remains a challenge.

Purpose of the Study:

To construct and investigate a thermoresponsive drug delivery system using LbL capsules.
To explore the influence of LbL architecture on dexamethasone release kinetics.

Main Methods:

Encapsulation of solid dexamethasone nanoparticles (DXM NPs) within a poly(diallyldimethylammonium chloride)/poly(styrenesulfonate) (PDAC/PSS) LbL assembly.
Systematic investigation of parameters including layer number, ionic strength, temperature, and outermost layer composition on drug release.

Main Results:

Increasing LbL layer number enhanced the nanoshell thickness and reduced dexamethasone release rate.
LbL assemblies fabricated without salt exhibited the highest temperature responsiveness and drug release contrast.
Drug release correlated with the size and concentration of free volume cavities within the LbL architecture.

Conclusions:

Tailoring LbL assembly properties, specifically free volume cavities, enables the creation of thermoresponsive drug delivery systems.
LbL assemblies can function as temperature-gated materials for controlled drug release, potentially reducing therapeutic toxic effects.