Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antipsychotic drug action, novel treatment targets, and the failure of current clinical trial designs in evaluating new target molecules.

Biological psychiatry·2026

Same author

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.

Journal of neurochemistry·2026

Same author

The ventral/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders.

Molecular psychiatry·2026

Same author

Novel positive allosteric modulators of alpha 5 subunit-containing GABA<sub>A</sub> receptors (α5-GABA<sub>A</sub>Rs) reverse the hyperdopaminergic state in a neurodevelopmental model of schizophrenia.

Schizophrenia research·2026

Same author

Executive function mediates the effects of genetic liability to schizophrenia on behavior and functioning in a community sample of children and adolescents.

Schizophrenia research·2026

Same author

Adolescent and adult stress alter excitatory-inhibitory network dynamics in the medial prefrontal cortex.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Genetic overlap between treatment-resistant schizophrenia and smoking initiation.

The international journal of neuropsychopharmacology·2026

Same journal

External Validation as the Critical Step for Predictive Biomarkers.

The international journal of neuropsychopharmacology·2026

Same journal

Viloxazine occupies the 5-HT2C receptor in the macaca fascicularis brain in vivo: A [11C]CIMBI-36 positron emission tomography study.

The international journal of neuropsychopharmacology·2026

Same journal

Divergent effects of interleukin-6 and ghrelin on remission and relapse in depression treatment.

The international journal of neuropsychopharmacology·2026

Same journal

Secondary Restless Legs Syndrome during psychopharmacological treatment: real-world evidence from a multinational pharmacovigilance program.

The international journal of neuropsychopharmacology·2026

Same journal

Recent cannabis exposure and acute nicotine effects: insights from randomized, double-blind, placebo-controlled intravenous nicotine studies.

The international journal of neuropsychopharmacology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 30, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model.

Kathryn M Gill¹, Anthony A Grace¹

¹Departments of Neuroscience, Psychiatry and Psychology,University of Pittsburgh,Pittsburgh, PA 15260,USA.

The International Journal of Neuropsychopharmacology

|May 3, 2014

Summary

This summary is machine-generated.

Schizophrenia models show reduced parvalbumin (PV) in the hippocampus (HPC). This study found PV loss in HPC subregions, indicating interneuron loss, particularly in the ventral dentate, impacting network activity.

More Related Videos

Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis

Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis

Published on: February 2, 2021

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Published on: July 29, 2018

Related Experiment Videos

Last Updated: Apr 30, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis

Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis

Published on: February 2, 2021

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Published on: July 29, 2018

Area of Science:

Neuroscience
Psychiatry
Cell Biology

Background:

Reduced parvalbumin (PV) expression in the hippocampus (HPC) is linked to schizophrenia.
It's unclear if this represents a loss of interneurons or reduced PV content.

Purpose of the Study:

To investigate PV and substance P (SP)-receptor co-expression in the HPC of the methylazoymethanol acetate (MAM) rat model of schizophrenia.
To differentiate between reduced PV content and actual interneuron loss.

Main Methods:

Immunohistochemical analysis of PV and SP-receptor co-expression in HPC subregions (dentate, CA3) of MAM and control rats.
Comparison of changes at post-natal day 27 (PND27) and post-natal day 240 (PND > 240).

Main Results:

Significant reductions in PV, but not SP-receptor, expression were observed in dorsal dentate, dorsal CA3, and ventral CA3 of MAM rats at both time points, indicating PV loss.
In the ventral dentate, reduced PV and SP-receptor co-expression was significant only in adult MAM rats (PND > 240), suggesting interneuron loss.

Conclusions:

The MAM rat model exhibits region-specific interneuron loss in the HPC, with a notable decrease in the ventral dentate in adulthood.
These findings highlight a loss of interneuron number, not just PV content, in specific HPC subregions, potentially affecting intra-HPC network function in schizophrenia models.