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Cerebral venous thrombosis and myeloproliferative neoplasms: results from two large databases

Francesco Dentali1, Walter Ageno1, Elisa Rumi2

  • 1Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.

Thrombosis Research
|May 3, 2014
PubMed
Abstract

Insights

Cerebral venous thrombosis (CVT) has a weak association with myeloproliferative neoplasms (MPNs). Routine MPN screening in CVT patients without overt myeloproliferative features may not be necessary.

Area of Science:

  • Hematology
  • Oncology
  • Neurology

Background:

  • Myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are associated with thrombosis.
  • While MPNs are linked to splanchnic vein thrombosis, their association with deep vein thrombosis and pulmonary embolism is less common.
  • Evidence regarding the prevalence of MPNs in cerebral venous thrombosis (CVT) patients and the incidence of CVT in MPN patients is limited and conflicting.

Purpose of the Study:

  • To investigate the frequency of MPNs in patients diagnosed with CVT.
  • To determine the incidence of CVT in a cohort of patients with established MPNs.

Main Methods:

  • Assessed MPN prevalence in 706 CVT patients.
  • Evaluated CVT incidence in a cohort of 2,143 MPN patients.

Main Results:

  • MPNs were diagnosed in 3.8% of CVT patients (27/706), with diagnosis occurring before, concomitantly, or after CVT.
  • CVT was diagnosed in 0.4% of MPN patients (9/2143), with a slightly higher frequency in PV (0.7%) compared to ET (0.3%) and PMF (0.2%).

Conclusions:

  • The study suggests a weak association between CVT and MPNs.
  • Thorough investigation for underlying MPNs may not be indicated for all CVT patients lacking overt myeloproliferative features.
Keywords:
Cerebral vein thrombosisMyelofibrosisPolycythemiaThrombocythemia

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