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Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters
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NanoClusters surface area allows nanoparticle dissolution with microparticle properties.

Christopher Kuehl1, Nashwa El-Gendy, Cory Berkland

  • 1Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, 66047.

Journal of Pharmaceutical Sciences
|May 3, 2014
PubMed
Summary

NanoClusters, agglomerates of nanoparticles, enhance drug dissolution rates for poorly soluble compounds. This micron-sized technology offers a promising alternative to nanoparticles for improving drug solubility and bioavailability.

Keywords:
NanoClustersbudesonidedanazoldissolutiondrug deliverymicroparticlesnanoparticlespowder technology

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Poorly water-soluble drugs represent a significant challenge in pharmaceutical development.
  • Nanoparticle agglomerates (NanoClusters) can enhance dissolution rates by increasing particle surface area.

Purpose of the Study:

  • To investigate the potential of NanoClusters as a strategy to improve the dissolution rate of poorly water-soluble drugs.
  • To evaluate the physicochemical properties and surface area of budesonide and danazol NanoClusters.

Main Methods:

  • NanoCluster suspensions were prepared using media milling (Netzsch MiniCer).
  • Physicochemical properties were analyzed using Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction.
  • Surface area was determined by Brunauer, Emmett and Teller (BET) analysis.
  • Particle size was confirmed using Scanning Electron Microscopy (SEM).

Main Results:

  • NanoClusters exhibited significantly increased surface area (8x for budesonide, 10-15x for danazol) compared to micronized stock.
  • NanoCluster samples demonstrated enhanced dissolution rates, comparable to dried nanoparticle suspensions.
  • Melting temperatures decreased with increased milling time, indicating altered physicochemical properties.

Conclusions:

  • NanoClusters offer a micron-sized alternative to nanoparticles for enhancing the dissolution of poorly water-soluble drugs.
  • Increased surface area is a key factor contributing to the improved dissolution rates observed with NanoClusters.