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Breakthrough invasive Candida glabrata in patients on micafungin: a novel FKS gene conversion correlated with

Takeshi Saraya1, Koichi Tanabe2, Koji Araki3

  • 1Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan sara@yd5.so-net.ne.jp.

Journal of Clinical Microbiology
|May 3, 2014
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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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