Related Experiment Video
Updated: Apr 30, 2026
04:19
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
Published on: November 8, 2024
1.8K
Treatment of painful Modic type I changes by vertebral augmentation with bioactive resorbable bone cement
Salvatore Masala1, Giovanni Carlo Anselmetti, Stefano Marcia
1Department of Diagnostic and Interventional Radiology, "Fondazione PTV"-Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Neuroradiology
|May 3, 2014
Summary
Vertebral augmentation using resorbable cement effectively treats persistent low back pain caused by Modic type I changes. Most patients experienced rapid pain relief and improved daily function within six months.
Area of Science:
- Orthopedics
- Spinal Surgery
- Pain Management
Background:
- Low back pain is a prevalent condition in industrialized nations.
- Modic type I changes represent acute end plate degenerative changes contributing to low back pain.
- Conservative treatments are often insufficient for persistent pain associated with Modic type I changes.
Purpose of the Study:
- To assess the efficacy of vertebral augmentation using calcium sulfate and hydroxyapatite resorbable cement.
- To evaluate treatment outcomes in patients with low back pain resistant to conservative therapies and linked to Modic type I changes.
Main Methods:
- A cohort of 218 patients with low back pain and Modic type I changes, unresponsive to conservative care, were selected.
- Patients underwent vertebral augmentation with resorbable cement.
- A 1-year follow-up period was implemented to monitor pain levels and functional improvement.
Main Results:
- 79% of patients reported rapid improvement within 4 weeks post-treatment.
- An additional 19% showed gradual improvement over 6 months, with comparable 1-year outcomes.
- Significant improvements in daily life activities were observed, although pain did not fully resolve in all patients.
Conclusions:
- Vertebroplasty with bioactive resorbable bone cement is a viable therapeutic option.
- This treatment effectively addresses low back pain originating from Modic type I end plate changes.
- The procedure demonstrates a favorable safety profile with no reported complications.
