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Induction of experimental allergic neuritis with synthetic peptides from myelin P2 protein
H C Shin1, E F McFarlane, J D Pollard
1School of Chemistry, University of Sydney, NSW, Australia.
Neuroscience Letters
|July 31, 1989
Abstract:
P2 protein and 4 synthetic peptides were tested for induction of experimental allergic neuritis (EAN). A peptide comprising the residues 62-78 of the bovine P2 protein sequence has been shown to contain an important neuritogenic determinant. A peptide comprising residues 66-78 produced no clinical symptoms of EAN. These results indicate that some or all of the residues 62 65 (Ile-Ser-Phe-Lys), are necessary for EAN induction.