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Personalised cancer medicine
Sarah E Jackson1, John D Chester1
1Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
International Journal of Cancer
|May 3, 2014
Summary
Personalised medicine revolutionizes cancer care by enabling targeted therapies and risk assessment. This approach tailors prevention and treatment strategies based on individual molecular profiles, improving patient outcomes.
Area of Science:
- Oncology
- Genetics
- Pharmacology
Background:
- Personalised medicine is increasingly vital in cancer care, influencing prevention, diagnosis, prognosis, and treatment.
- Individualised, molecularly targeted therapies are now in routine clinical practice, offering improved efficacy and reduced toxicity.
Purpose of the Study:
- To review the role of personalised medicine in cancer prevention and treatment.
- To discuss the future directions of personalised medicine in oncology.
Main Methods:
- Review of current literature on personalised medicine in oncology.
- Analysis of targeted therapies and their molecular targets.
- Discussion of genetic predisposition and risk-modification strategies.
Main Results:
- Personalised medicine allows for identification of at-risk individuals through genetic screening (e.g., BRCA genes).
- Molecularly distinct cancer subtypes necessitate tailored therapeutic approaches using targeted agents like monoclonal antibodies and tyrosine kinase inhibitors.
- Treatment decisions are shifting towards tumour molecular profiles rather than traditional tissue type or location.
Conclusions:
- Personalised medicine is transforming cancer care, leading to better patient prognosis and quality of life.
- The future of oncology lies in molecularly driven treatment strategies.
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